The urinary recovery of unchanged drug is reported to be approximately 36% of the oral dose when renal function is normal. Apr 01, 2019 hydroxyurea is excreted by the kidney, and the risk of adverse reactions to this drug may be greater in patients with impaired renal function. It is used with chemoradiation the use of hydroxyurea to treat cancer is approved for the hydrea brand. Use with other myelosuppressive agents or radiation may increase the likelihood of bone marrow depression or other adverse. Reduce the dose of hydrea by 50% in patients with measured creatinine clearance of less than. Hydroxyurea fda prescribing information, side effects and uses. Increase dose 5 mgkgday every 12 weeks to a maximum dose of 35 mgkgday maximal dose is the highest dose that does not produce toxic blood counts over 24 consecutive weeks. Hydroxyurea alters the red blood cell membrane so it.
Hydroxyurea is not approved by the fda for use in children with sickle cell disease. Obtain baseline labs as above prior to initiating hydroxyurea. Hydroxyurea capsules, usp can cause fetal harm when administered to a pregnant woman. Hydroxycarbamide, also known as hydroxyurea, is a medication used in sicklecell disease, chronic myelogenous leukemia, cervical cancer, and polycythemia vera. Find patient medical information for hydroxyurea bulk on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Fda label information for this drug is available at dailymed.
Hydroxyurea causes an accumulation of cells at the g1sphase or the early sphase of the cell cycle, which leads to cell death. Dec 18, 2014 hydroxyurea compared with placebo did not prevent early evidence of renal or splenic dysfunction in toddlers aged 9 to 18 months table 1, 15 but observational studies in children aged 9 months to 20 years noted significant improvement in splenic uptake, glomerular filtration rate, renal hypertrophy, ability to concentrate urine. Hydroxyurea is excreted by the kidney, and the risk of adverse reactions to this drug may be greater in patients with impaired renal function. Alternatively, hydroxyurea may be beneficial, even though hydroxyurearelated skin ulcers have been reported. After oral administration, hydroxyurea is readily absorbed. Patients with normal renal function creatinine clearance crcl 80 mlmin, mild crcl 50 to 80 mlmin, moderate crcl 30 to renal impairment received a single oral dose of 15 mgkg hydroxyurea. Hydroxyurea hydrea, droxia is a prescription drug used to treat several types of cancer including types of leukemia, head and neck cancer, malignant melanoma, and ovarian cancer. Novel dose escalation to predict treatment with hydroxyurea. Kintzel pe and dorr rt, anticancer drug renal toxicity and elimination. Prolongation of the drug halflife and reduced clearances of the drug and its metabolites may occur. Dose adjustments are typically made based on stages of ckd, with gfr 90, 6089, 3059, 1529, book is available from the british library. Dosing guidelines book dosing guidelines for children dosing guidelines for adults. Hydrea hydroxyurea capsules, usp is an antimetabolite available for oral use as capsules containing 500 mg hydroxyurea. Hydroxyurea, a hydroxylated molecule of urea, interferes with the synthesis of.
Oct 09, 2019 hydroxyurea is excreted by the kidney, and the risk of adverse reactions to this drug may be greater in patients with impaired renal function. Hydrea hydroxyurea side effects, images, uses, dosage. A catalogue record for this book is available from the british library. Use of this medication in children with sickle cell disease is recommended by the nhlbi guidelines published in jama cited in reference 1. Try not to miss your dose of hydroxyurea, but if you do, take it as soon as possible. Includes dosages for chronic myelogenous leukemia, sickle cell anemia and head and neck cancer. Its used to treat psoriasis, chronic myelogenous leukemia a cancer of the white blood cells, ovarian cancer, melanoma a. Give with caution to clients with marked renal dysfunction. Contact your doctor or pharmacist for instructions on how to dispose of outdated capsules. Reduce the dose from the dose associated with hematologic toxicity. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function see dosage and administration 2. Hydroxyurea hydrea is used alone or with other medications or radiation therapy to treat a certain type of chronic myelogenous leukemia cml.
Analgesics antihypertensive and cardiovascular agents antimicrobial agents miscellaneous agents sedatives, hypnotics, and other drugs used in psychiatry. Hydroxyurea hydrea side effects, dosage, interactions. Pediatric drugs analgesics antihypertensive and cardiovascular agents antimicrobial agents miscellaneous agents sedatives, hypnotics, and other drugs used in psychiatry. The information on dosage adjustments in renal impairment given in this book is based on. Hydroxyurea should be used with caution in patients with preexisting renal dysfunction. The patient should be at a stable dose with no hematologic toxicity for 24 weeks. Hydroxyurea is the only major drug breakthrough for the treatment of sickle cell disease within the past 20 years. Detailed hydroxyzine dosage information for adults and children. Cautionrenal dysfunction, concurrent myelosuppressive agents. Click here for a specialized list of other renal medication dosing not listed in the alphabetical main section simple renal dosing guidelines. Hydroxyurea dosage, interactions, side effects, how to use. The approaches that are available for reducing these pathophysiologic processes are regular red blood cell rbc transfusions, hydroxyurea therapy, and hematopoietic cell transplantation hct. Excretion excretion of hydroxyurea in humans is a nonlinear process occurring through two pathways. Effect of hydroxyurea treatment on renal function parameters.
Hydroxyurea enters human breast milk with a relative infant dose of about 4. All patients will be offered the choice of a liquid formulation of hydroxyurea or hydroxyurea tablets, with the exact dose rounded up or down to the closest practical dose based on the chosen formulation but not differing from the intended dose by more. Rasburicase fasturtec is a novel uricolytic agent that. The authors make no claims of the accuracy of the information contained herein. Patients can be managed initially with hydroxyurea and transitioned to chronic diseasemodifying therapies for prevention of vasoocclusive pain in sickle cell disease. Geriatric clients may be more sensitive to the effects of hydroxyurea necessitating a lower dose. This book is distributed under the terms of the creative commons attribution 4. Hydroxyurea alters the red blood cell membrane so it is unable to penetrate the capillaries of the skin. In psoriasis, the result of hydroxyurea therapy is a slowing of basal celllayer replication. Alvarez o1, miller st, wang wc, luo z, mccarville mb, schwartz gj, thompson b, howard t, iyer rv, rana sr, rogers zr, sarnaik sa, thornburg cd, ware re. Elise anderes, sucha nand, in handbook of clinical neurology, 2014. Dosing guidelines book school of medicine university of.
Highlights of prescribing information these highlights do. Apr 25, 2019 follow dosing instructions very carefully. Hydroxyurea has been demonstrated to be a potent teratogen in a wide variety of animal models, including mice, hamsters, cats, miniature swine, dogs and monkeys at doses within 1. Hydroxyurea information, side effects, warnings and recalls. Chronic myelogenous leukemia that is refractory does not respond to treatment squamous cell carcinoma of the head and neck excluding the lip that is locally advanced. Hydroxyurea side effects, uses, dosage, overdose, pregnancy. Renal dosage adjustment guidelines for antimicrobials. Prophylactic administration of folic acid is recommended. Detailed hydroxyurea dosage information for adults and children. Its free to register and youll have access to drug information and much more. Constipation, redness of the face, maculopapular rash. Minor complications of hydroxyureas use may include skin rash or ulceration, erythema, alopecia, stomatitis, anorexia, vomiting, and diarrhea. Hydrea hydroxyurea dose, indications, adverse effects.
Hydroxyurea is excreted in the urine with recommendations of dose change in patients with kidney function impairment. Trivalent forms of arsenic are methylated in humans and mostly excreted in urine. Hydroxyurea 15 mgkg round up to nearest 500 mg daily. On the basis of the exposure and the apparent clearance from the current and 2 historical studies, the authors have proposed an initial dosing regimen of hydroxyurea 7. Your cancer treatments may be delayed based on the results. Adult drugs analgesics antihypertensive and cardiovascular agents antimicrobial agents miscellaneous agents sedatives, hypnotics, and other drugs used in. Includes dosages for anxiety, nauseavomiting, sedation and more. This medicine can affect the results of certain medical tests.
Renal drug handbook gfr 2050mlsmin dose as in normal renal function, 1020mlsmin give. Dose modifications for renal impairment reduce the dose of hydrea by 50% in patients with measured creatinine clearance of less than 60 mlmin or with endstage renal disease esrd see use in specific populations 8. Find comprehensive medical reference information including disease symptoms, diagnoses, treatments, and followup. Aug 22, 2012 hydroxyurea should be kept out of the reach of children and pets. Neither hydroxyzine or the metabolite, cetirizine, are appreciably removed during dialysis, and accumulation may occur in patients with renal failure. Hydroxyurea oral capsule is available as the brandname drugs hydrea and droxia. Enrollment grows in the ptn hydroxyurea study the ptns hydroxyurea hu study is kicking into high gear, with sites reportedly expecting an influx of at least 5 newly enrolled patients over the upcoming spring holiday. Arrange reliable contraception for while on hydroxyurea. The renal drug handbook the st georges hospital, adult critical.
Dosing after hematologic recovery reduce dose by 5 mgkgday from the dose associated with hematologic toxicity. Hydroxyurea and are likely due to the chronic cumulative toxicity of hydroxyurea or one of its metabolites. Heparin lowmolecularweight, hydralazine, hydrochlorothiazide, hydrocortisone, hydroflumethiazide, hydroxyurea, hydroxyzine, ibuprofen, idarubicin. The level of renal function below which the dose of a drug must be reduced depends largely on the extent of renal metabolism and elimination, and on the drugs toxicity. Side effects, drug interactions, warnings, precautions, dosing, storage, pregnancy, and breastfeeding safety information is included.
Droxia causes macrocytosis, which may mask the incidental development of folic acid deficiency. The pharmacists will automatically adjust the doses of any of the antimicrobials included in the protocol according to the estimated creatinine clearance generally using the cockroftgault equation for patients. Prescription drug information for thousands of brand, generic, and otc medicines is available to registered members only. Hydroxyurea is a prescription drug sold under the brand name hydrea. Considering hydroxyurea is a potent mutagen, breastfeeding should perhaps be avoided for 1224 h after receiving a dose. Use hydroxyzine with caution in patients with moderate to severe renal impairment. Erythrocyte abnormalities including megaloblastic erythropoiesis. Update on the use of hydroxyurea therapy in sickle cell disease. Hydroxyurea fda prescribing information, side effects. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Hydroxyurea daviss drug guide for rehabilitation professionals. Hydroxyurea in pediatric patients with sickle cell anemia. Hydroxyurea hydrea side effects, dosage, interactions drugs.